Formed in 1893 as a breakaway from the Ayrshire Football League. Its original membership was Annbank F.C., Ayr F.C., Ayr Parkhouse F.C., Hurlford F.C., Kilbirnie, Kilmarnock F.C. and Stevenston Thistle F.C..
In 1897 Ayr F.C. joined the Scottish Football League and this sounded the death knell of the Combination.
Champions
1893–94 Annbank
1894–95 Ayr
1895–96 Ayr
1896–97 Ayr
Membership
Annbank 1893–1895
Ayr 1893–1897
Ayr Parkhouse 1893–1897
Beith1895–1897
Galston 1896–1897
Hurlford 1893–1897
Irvine 1895–1897
Kilbirnie 1893–18894
Kilmarnock 1893–1895
Kilmarnock Athletic 1894–1896
Kilwinning Monkcastle 1894–1897
Salcoats Victoria 1894–1895
Stevenson Thistle 1893–1897
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